Imaging Nigral Pathology and Clinical Progression in Parkinson's Disease
Identifieur interne : 001095 ( Main/Exploration ); précédent : 001094; suivant : 001096Imaging Nigral Pathology and Clinical Progression in Parkinson's Disease
Auteurs : GUANGWEI DU [États-Unis] ; Mechelle M. Lewis [États-Unis] ; Suman Sen [États-Unis] ; JIANLI WANG [États-Unis] ; Michele L. Shaffer [États-Unis] ; Martin Styner [États-Unis] ; Qing X. Yang [États-Unis] ; XUEMEI HUANG [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
The pattern of dopamine cell loss in Parkinson's disease (PD) is known to be prominent in the ventrolateral and caudal substantia nigra (SN), but less severe in the dorsal and rostral region. Both diffusion tensor imaging (DTI) and R2* relaxometry of the SN have been reported as potential markers for PD, but their relative ability to mark disease progression and differences in pathophysiological bases remains unclear. High-resolution T2-weighted, R2*, and DTI were obtained from 28 controls and 40 PD subjects [15 early stage [disease duration ≤1 year], 14 mid stage [duration 2-5 years], and 11 late stage [duration >5 years]). Fractional anisotropy and R2* values in both rostral and caudal SN were obtained for all subjects, and clinical measures (e.g., disease duration, levodopa-equivalent daily dosage, and "off"-drug UPDRS motor score) were obtained for Parkinson's subjects. There was no correlation between fractional anisotropy and clinical measures, whereas R2* was strongly associated with disease progression. Compared to controls, fractional anisotropy in caudal SN was significantly decreased in PD patients of all stages, whereas in rostral SN, it was decreased significantly only in the late-stage group. R2* in both SN regions was significantly increased in the mid- and late-stage, but not early-stage, of PD subjects. These findings suggest that fractional anisotropy changes may mark early pathological changes in caudal SN, whereas the changes in R2* may more closely track PD's clinical progression after symptom onset.
Affiliations:
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Yang</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Bioengineering, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Pennsylvania State University-Milton S. 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Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Sen, Suman" sort="Sen, Suman" uniqKey="Sen S" first="Suman" last="Sen">Suman Sen</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Jianli Wang" sort="Jianli Wang" uniqKey="Jianli Wang" last="Jianli Wang">JIANLI WANG</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Shaffer, Michele L" sort="Shaffer, Michele L" uniqKey="Shaffer M" first="Michele L." last="Shaffer">Michele L. Shaffer</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Styner, Martin" sort="Styner, Martin" uniqKey="Styner M" first="Martin" last="Styner">Martin Styner</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Computer Science, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Psychiatry, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Yang, Qing X" sort="Yang, Qing X" uniqKey="Yang Q" first="Qing X." last="Yang">Qing X. Yang</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Bioengineering, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Bioengineering, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Department of Neurology, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term><term>Diffusion tensor imaging</term><term>Locus niger</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term><term>Relaxation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Anatomopathologie</term><term>Locus niger</term><term>Imagerie du tenseur de diffusion</term><term>Relaxation</term><term>Imagerie RMN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pattern of dopamine cell loss in Parkinson's disease (PD) is known to be prominent in the ventrolateral and caudal substantia nigra (SN), but less severe in the dorsal and rostral region. Both diffusion tensor imaging (DTI) and R2<sup>*</sup> relaxometry of the SN have been reported as potential markers for PD, but their relative ability to mark disease progression and differences in pathophysiological bases remains unclear. High-resolution T2-weighted, R2<sup>*</sup>, and DTI were obtained from 28 controls and 40 PD subjects [15 early stage [disease duration ≤1 year], 14 mid stage [duration 2-5 years], and 11 late stage [duration >5 years]). Fractional anisotropy and R2<sup>*</sup> values in both rostral and caudal SN were obtained for all subjects, and clinical measures (e.g., disease duration, levodopa-equivalent daily dosage, and "off"-drug UPDRS motor score) were obtained for Parkinson's subjects. There was no correlation between fractional anisotropy and clinical measures, whereas R2<sup>*</sup> was strongly associated with disease progression. Compared to controls, fractional anisotropy in caudal SN was significantly decreased in PD patients of all stages, whereas in rostral SN, it was decreased significantly only in the late-stage group. R2<sup>*</sup> in both SN regions was significantly increased in the mid- and late-stage, but not early-stage, of PD subjects. These findings suggest that fractional anisotropy changes may mark early pathological changes in caudal SN, whereas the changes in R2<sup>*</sup> may more closely track PD's clinical progression after symptom onset.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Guangwei Du" sort="Guangwei Du" uniqKey="Guangwei Du" last="Guangwei Du">GUANGWEI DU</name></region><name sortKey="Jianli Wang" sort="Jianli Wang" uniqKey="Jianli Wang" last="Jianli Wang">JIANLI WANG</name><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name><name sortKey="Sen, Suman" sort="Sen, Suman" uniqKey="Sen S" first="Suman" last="Sen">Suman Sen</name><name sortKey="Shaffer, Michele L" sort="Shaffer, Michele L" uniqKey="Shaffer M" first="Michele L." last="Shaffer">Michele L. Shaffer</name><name sortKey="Styner, Martin" sort="Styner, Martin" uniqKey="Styner M" first="Martin" last="Styner">Martin Styner</name><name sortKey="Styner, Martin" sort="Styner, Martin" uniqKey="Styner M" first="Martin" last="Styner">Martin Styner</name><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><name sortKey="Yang, Qing X" sort="Yang, Qing X" uniqKey="Yang Q" first="Qing X." last="Yang">Qing X. Yang</name><name sortKey="Yang, Qing X" sort="Yang, Qing X" uniqKey="Yang Q" first="Qing X." last="Yang">Qing X. Yang</name><name sortKey="Yang, Qing X" sort="Yang, Qing X" uniqKey="Yang Q" first="Qing X." last="Yang">Qing X. Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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